BIOGRAPHICAL SKETCH

 

 

NAME

 

ALI, Syed F.

POSITION TITLE

Senior Biomedical Research Scientist

Head, Neurochemistry Laboratory 

 

 

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Aligarh Muslim University, Aligarh, India

Aligarh Muslim University, Aligarh, India

Brain Res. Ctr., AMU, Aligarh, India

Brain, Res. Ctr., AMU, Aligarh, India  

B.Sc. (Hons)

M.Sc.

M. Phil

Ph.D.

1973

1975

1977

1980

Chemistry

Chemistry (Organic)

Neurochemistry

Neurotox/Neurochem

    BNT, N.I.E.H.S., Res. Tri. Park, NC, USA

Post-doctoral

1981

Neurotox/Neurochem

 

Professional Experience

1976-1979:      Jr. Res. Fellow and Sr. Res. Fellow, Brain Res. Center, J.N. Medical College, Aligarh Muslim University, Aligarh, India.

1980-1981:      Post-doc. Res. Fellow, Brain Res. Ctr. J.N. Med. Coll., AMU, Aligarh, India.

1981-1982:      Fogarty Research Fellow, NIEHS, Research Triangle Park, NC.

1983-1984:      Res. Assoc., Depts. Biochem. and Med., Univ. of Ark. Med. Sci., Little Rock, AR.

1984-1986:      Staff Fellow, Div. Reprod. and Develop. Toxicol., NCTR/FDA, Jefferson, AR.

1986-present:  Head, Neurochem. Lab., Div. of Neurotoxicology, NCTR/FDA, Jefferson, AR.

1990-present:  Adj. Prof., Dept. Biochem. & Mol. Biol., Univ. of Ark. Med. Sci., Little Rock, AR.

1991-present:  Adj. Prof., School of Pharmacy, Univ. Miss., University, MS.

1992-present: Adj. Prof., College of Pharmacy, Northeast Louisiana Univ., Monroe, LA

1996-present:  Adj. Prof., Dept. Neurology, Univ. Ark. Med Sci., Little Rock, AR

    2000 – present:       Senior Biomedical Research Scientist (SBRS), NCTR/FDA           

Honors

International Brain Research Organization

International Society for Neurochemistry

International Society for Developmental Neuroscience

Society of Neuroscience (U.S.A.)

American Society of Neurochemistry

Society of Toxicology (U.S.A)

South Central Regional Chapter of S.O.T. (U.S.A.)

American Association for the Advancement of Science

 

Publications: Selected Bibliography on Neurochemistry: (from 250 publications)

 

1.              Binienda, Z.K., Pereira, F., Alper, K., Slikker, W.,Jr. and Ali, S.F. Adaptation to repeated cocaine administration in rats. Ann N.Y. Acad. Sci.  965: 172-179, 2002.

2.             Gough, B., Imam, S.Z., Blough, B., Slikker, W., Jr. and Ali, S.F.  Comparative effects of substituted amphetamines (PMA, MDMA, and METH) on monoamines in rat caudate. Ann N.Y. Acad. Sci.  965: 410-420, 2002.

3.             Imam, S.Z., Newport, G.D., Duhart, H.M., Islam, F., Slikker, W., Jr. and Ali, S.F.  Methamphetamine-induced dopaminergic neurotoxicity and production of peroxynitrite are potentiated in nerve growth factor differentiated pheochromocytoma 12 cells. Ann N.Y. Acad. Sci.  965: 204-213, 2002.

 

 

 

4.             Itzhak, Y., Martin, J.L., and Ali, S.F.. Methamphetamine-induced dopaminergic neurotoxicity in mice long lasting sensitization to the locomotor stimulation and desensitization to the rewarding effects of methamphetamine.  Progress in Neuro-Psychopharmacology & Biological Psychiatry  26:1177-1183, 2002

5.             Onaivi, E.S., Ali, S.F., Chirwa, S.S., Zwiller, J.,Thiriet, N., Akinshola, B.E. and Ishiguro, H... Ibogaine signals addiction genes and methamphetamine alteration of long-term potentiation. Ann N.Y. Acad. Sci.  965: 28-46, 2002

6.             Baumann, M.H., Phillips, J.M., Ayestas, M.A., Ali, S.F., Rice, K.C. and Rothman, R... Ann Pre clinical evaluation of GBR12909 deaconate as a long-acting medication for methamphetamine dependence.  N.Y. Acad. Sci.  965: 92-108, 2002.

7.             Itzhak, Y and Ali, S.F.  Behavioral Consequences of Methamphetamine-induced neurotoxicity in mice: Relevance to the Psychopathology of methamphetamine addiction. Ann N.Y. Acad. Sci.  965: 127-135, 2002.

8.             Virmani, A., Gaetani, F., Imam, S.Z., Binienda, Z. and Ali, S.F. The protective role of L-Carnitine against Neurotoxicity evoked by drug of abuse, Methamphetamine, Could be related to mitochondrial dysfunction. Ann N.Y. Acad. Sci.  965: 225-232, 2002.

9.             Chera, B., Schaecher, K.E., Rocchini, A., Imam, S.Z., Ray, S.K., Ali, S.F. and Banik, N.L. Calpain Upregulation and neuron death in spinal cord of MPTP-induced Parkinsonism in mice. Ann N.Y. Acad. Sci.  965: 274-280, 2002.

10.         Itzhak, Y. and Ali, S.F.  Repeated administration of Gamma-Hydroxybutyric Acid (GHB) to mice: assessment of the sedative and rewarding effects of GHB. Ann N.Y. Acad. Sci.  965: 451-460, 2002.

11.         Pereira, F.C., Imam, S.Z., Gough, B., Newport, G.D., Ribeiro, C.F., Slikker, W. Jr., Macedo, T.R. and Ali, S.F...  Acute changes in dopamine release and turnover in rat caudate nucleus following a single dose of methamphetamine.  J. Neural Transm. 109: 1151-1158, 2002.

12.         Hussain, S. and Ali, S.F...  Zinc potentiates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced dopamine depletion in caudate nucleus of mice brain.  Neurosci. Letts., 335: 25-28, 2002

13.         Feng, Z.,-H., Wang, T.-G., Li, D.-D., Fung, P., Wilson, B.C., Liu, B., Ali, S.F., Langenbach, R., Hong, J.-S. . Cyclooxygenase-2-deficient mice are resistant to 1-methyl-4-phenyl1,2,3,6- tetrahydropyridine-induced damage of dopaminergic neurons in the substantia nigra.  Neurosci. Letts., 329: 354-358, 2002

14.         Zhang, C., Imam, S.Z., Ali, S.F., Mayeux, P.R., Peroxynitrite and the regulation of Na(+), K(+)-ATPase activity by angiotesin II in the rat proximal tubule., Nitric Oxide, 7:30-35,  2002.

15.         Goering, Peter L., Morgan, Daniel L., and Ali, Syed F., Effects of Mercury vapor inhalation on reactive oxygen species and antioxidant enzymes in rat brain and kidney are minimal., J. Appl. Toxicol., 22: 167-172, 2002.                                           

16.         Jedynak, Jakub P., Ali, Syed F., Haycock, John W., Hope, Bruce T., Acute administration of cocaine regulates the phosphorylation of serine-19, -31 and -40 in tyrosine hydroxylase. J. Neurochem, 82(2):382-388, 2002.

17.         Meyer, J.S., Ali, S.F., Serotonergic neurotoxicity of MDMA(ecstasy) in the developing rat brain. Ann N.Y. Acad. Sci. 965:373-80, 2002.

18.         Whittaker, P. Ali, S.F., Imam, S.Z., Dunker, V.C., Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. Reg. Tox. & Pharmacol., 36:280-286, 2002.

19.         Riegel, A.C., Ali, S.F., French, E. Toluene-induced locomotor activity is blocked by 6-hydoxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268.  Neuropsychopharmacology, 28:1440-1447, 2003.

20.         Itzhak, Y., Ali, S.F., Achat, C.N., Anderson,K.L. Relevance of MDMA (“ecstasy”)-induced neurotoxicity to long-lasting psychomotor stimulation in mice. Psychopharmacology, 166:241-248, 2003.

21.         Santamaria, A., Salvatierra-Sanchez, R., Vazquez-Roman, B., Santiago-Lopez, D., Villeda-Hernandez, J., Galvan-Arzate, S., Jimenez-Capdeville, M.E., Ali, S.F. Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies. J. Neurochem., 86: 479-8, 2003.

22.         Imam, S.Z., Oetinger, M., Skinner, J., Slikker, W., Jr., Ali, S.F.  The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicity. Ann N.Y. Acad. Sci.  993: 387-393, 2003.

23.         Imam, S.Z., Duhart, H.M., Skinner, J.T., Ali, S.F.  Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells. Ann N.Y. Acad. Sci.  993: 362, 2003.

24.         Bowyer, J.F., Young, J.F., Slikker,W., Itzhak, Y.,Mayorga, A.J., Newport, G.D., Ali, S.F., Frederick, D.L., Paule, M.G. Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations. Neurotoxicology, 24:379-390, 2003.

25.         He, Yi, Imam, Syed Z., Dong, Zaojun, Jankovic, Joseph, Ali, Syed F., Appel, Stanley H., Le, Weidong   Role of nitric oxide in rotenone-induced nigro-striatal injury. J. Neurochem, 86, 1338-1345, 2003

26.         Pereira, F.C., Macedo, T.R., Imam, S.Z., Ribeiro, C.F., and Ali, S.F., Lack of Hydroxyl Radical Generation upon Central Administration of Methamphetamine in Rat Caudate Nucleus: a Microdialysis Study. Neurotoxicity Res, 6, 1 - 4, 2004.

27.         Zhang W, Wang, T., Qin L., Gao H.M., Wilson, B., Ali, S.F., Zhang, W.,Hong, J.S., Liu, B., Neuroprotective effect of dexromethorphan in the MPTP Parkinson’s disease model: role of NADPH oxidase. FASEB, J.,  5, 18(3): 589 - 591, 2004.

28.         Santiago-Lopez, Dario, Vazquez-Roman, Beatriz, Barrera, Diana, Rembao, Daniel,  Pedraza-Chaverri, Jose, Galvan-Arzate, Sonia,  Al, S.F., Santamaria, Abel. Peroxynitrite Decomposition Catalyst, Iron Metalloporphine, Reduces Quinolinate-induced Neurotoxicity in Rats. Synapses 54: 233-238, 2004.

29.         Virmani, A., Gaetani, F., Binienda, Z.K., Xu, Z., Duhart, H. M., Ali, S.F., Role of mitochondrial dysfunction in neurotoxicity of MPP+: Partial protection of PC12 cells by acetyl-1-carnitine. Ann N.Y. Acad. Sci. 1025:267-273, 2004.

30.         Pereira, F.C., Santos, S.D., Ribeiro, C.F., Ali,S.F., Macedo, T. R., A Single exposure to morphine induces long-lasting hyporeactivity of rat caudate putamen dopaminergic nerve terminals, Ann N.Y. Acad. Sci. 1025:414-423, 2004.

31.         Riegel, A.C., Ali, S.F., Torinese, S. French, E.D., Repeated Exposure to the abused  inhalant Toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Ann N.Y. Acad. Sci. 1025:543-551, 2004.

32.         Chera, B., Schaecher, K., Rocchini, A., Imam, S. Z., Sribnick, E., Ray, S.K., Ali, S. F., Banik, N.L., Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain Res. 1006:150-156, 2004.

33.         Dass, S. B., and  Ali, S.F., Evaluation of  γ-Hydroxybutyric Acid for Genotoxicity in the Mouse Micronucleus Assay.  Ann N.Y. Acad. Sci. 1025:538-542, 2004.

34.    Itzhak, Y., Anderson, K. L., and Ali, S.F., Differential response of nNOS knockout mice to MDMA (“Escstasy”) and methamphetamine-induced psychomotor sensitization and neurotoxicity. Ann N.Y. Acad. Sci. 1025:119-128, 2004.

35.     Meyer, J.S., Grande, M., Johnson, K., Ali, S.F., Neurotoxic effects of MDMA (“ecstasy”) administration to neonatal rats. Int. J. Devl Neuroscience 22:261–271, 2004

36.    Achat-Mendes, C., Ali, S.F., Itzhak, Y.,  Differential Effects of Amphetamines-Induced Neurotoxicity on Appetitive and Aversive Pavlovian Conditioning in Mice. Neuropsychopharmacology, 2005.

37.    Xu, Z., Cawthon, D., McCastlain, K.A., Slikker, W. Jr. and Ali, S.F.  Selective alterations of                gene expression in mice induced by MPTP.  Synapse 55:45-51, 2005. 

38.        Riegel, A.C., Ali, S.F., French, E. Toluene-induced locomotor activity is blocked by 6-hydoxydopamine       lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268.  Neuropsychopharacology, 28:1440-1447, 2003.

39.        Itzhak, Y., Ali, S.F., Achat, C.N., Anderson,K.L. Relevance of MDMA (“ecstasy”)-induced neurotoxicity to long-lasting psychomotor stimulation in mice. Psychopharmacology, 166:241-248, 2003.

40.        Santamaria, A., Salvatierra-Sanchez, R., Vazquez-Roman, B., Santiago-Lopez, D., Villeda-Hernandez, J., Galvan-Arzate, S., Jimenez-Capdeville, M.E., Ali, S.F. Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies. J. Neurochem., 86: 479-8, 2003.

41.        Imam, S.Z., Oetinger, M., Skinner, J., Slikker, W., Jr., Ali, S.F.  The role of caspase III inhibition in methamphetamine-induced alterations in p53 and bcl-2 expression: correlation with dopaminergic neurotoxicity. Ann N.Y. Acad. Sci.  993: 387-393, 2003.

 

 

 

 

42.        Imam, S.Z., Duhart, H.M., Skinner, J.T., Ali, S.F.  Cocaine induces a dose-dependent alteration in the expression of immediate early genes c-fos and SP-1 and in nuclear factor NF-kappabeta in PC12 cells. Ann N.Y. Acad. Sci.  993: 362, 2003.

43.        Bowyer, J.F., Young, J.F., Slikker,W., Itzhak, Y.,Mayorga, A.J., Newport, G.D., Ali, S.F., Frederick, D.L., Paule, M.G. Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations. Neurotoxicology, 24:379-390, 2003.

44.        He, Yi, Imam, Syed Z., Dong, Zaojun, Jankovic, Joseph, Ali, Syed F., Appel, Stanley H., Le, Weidong   Role of nitric oxide in rotenone-induced nigro-striatal injury. J. Neurochem, 86, 1338-1345, 2003

45.        Pereira, F.C., Macedo, T.R., Imam, S.Z., Ribeiro, C.F., and Ali, S.F., Lack of Hydroxyl Radical Generation upon Central Administraition of Methamphetamine in Rat Caudate Nucleus: a Microdialysis Study. Neurotoxicity Res, 6, 1 - 4, 2004.

46.        Zhang W, Wang, T., Qin L., Gao H.M., Wilson, B., Ali, S.F., Zhang, W.,Hong, J.S., Liu, B., Neuroprotective effect of dexromethorphan in the MPTP Parkinson’s disease model: role of NADPH oxidase. FASEB, J.,  5, 18(3): 589 - 591, 2004.

47.        Santiago-Lopez, Dario, Vazquez-Roman, Beatriz, Barrera, Diana, Rembao, Daniel,  Pedraza-Chaverri, Jose, Galvan-Arzate, Sonia,  Al, S.F., Santamaria, Abel. Peroxynitrite Decompostion Catalyst, Iron Metalloporphine, Reduces Quinolinate-induced Neurotoxicity  in Rats. Synapses 54: 233-238, 2004.

48.        Virmani, A., Gaetani, F., Binienda, Z.K., Xu, Z., Duhart, H. M., Ali, S.F., Role of mitochondrial dysfunction in neurotoxicity of MPP+: Partial protection of PC12 cells by acetyl-1-carnitine. Ann N.Y. Acad. Sci. 1025:267-273, 2004.

49.        Pereira, F.C., Santos, S.D., Ribeiro, C.F., Ali,S.F., Macedo, T. R., A Single exposure to morphine induces long-lasting hyporeactivity of rat caudate putamen dopaminergic nerve terminals, Ann N.Y. Acad. Sci. 1025:414-423, 2004.

50.        Riegel, A.C., Ali, S.F., Torinese, S. French, E.D., Repeated Exposure to the abused  inhalant Toluene alters levels of neurotransmitters and generates peroxynitrite in nigrostriatal and mesolimbic nuclei in rat. Ann N.Y. Acad. Sci. 1025:543-551, 2004.

51.        Chera, B., Schaecher, K., Rocchini, A., Imam, S. Z., Sribnick, E., Ray, S.K., Ali, S. F., Banik, N.L., Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain Res. 1006:150-156, 2004.

52.        Dass, S. B., and  Ali, S.F., Evaluation of  γ-Hydroxybutyric Acid for Genotoxicity in the Mouse Micronucleus Assay.  Ann N.Y. Acad. Sci. 1025:538-542, 2004.

53.        244.     Itzhak, Y., Anderson, K. L., and Ali, S.F., Differential response of nNOS knockout mice to MDMA (“Escstasy”) and methamphetamine-induced psychomotor sensitization and neurotoxicity. Ann N.Y. Acad. Sci. 1025:119-128, 2004.

54.        245.     Meyer, J.S., Grande, M., Johnson, K., Ali, S.F., Neurotoxic effects of MDMA (“ecstasy”) administration to neonatal rats. Int. J. Devl Neuroscience 22:261–271, 2004

55.        246.     Achat-Mendes, C., Ali, S.F., Itzhak, Y.,  Differential Effects of Amphetamines-Induced Neurotoxicity on Appetitive and Aversive Pavlovian Conditioning in Mice. Neuropsychopharmacology,  10:1-10, 2005.

56.        Xu, Z., Cawthon, D., McCastlain, K.A., Slikker, W. Jr. and Ali, S.F.  Selective alterations of    gene expression in mice induced by MPTP.  Synapse 55:45-51, 2005.          

57.        Przybyla-Zawislak, Beata D., Kim, Chung S., Ali, Syed F., Slikker, Jr., William, Binienda, Zbigniew , The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver. Neurosci. Letts., 381: 354-357, 2005.

58.        Z. Xu, Cawthon, D., McCastlain, K.A., Duhart, H.M., Newport, G.D., Fang, H., Patterson, T.A., Slikker, Jr.,W., Ali, S.F., Selective Alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells. Neurotoxicology. 26: 729-737, 2005.

59.        Soderblom, E.J., Cawthon, D., Duhart, H., Xu, Z. A., Slikker, Jr., Ali, S. and Goshe, M., An improvided labeling method using Phosphor-Protein isotope-coded Solid-phase tags for neuronal cell applications. Int J Neuroprotec Neuroregen 1(2): 91-97, 2005.

60.        Cawthon, D., Soderblom, E.J., Z. Xu, Duhart, H.M., Slikker, Jr.,W., Ali, S.F. and Goshe, M., Quantitative analysis of Phosphoproteins in a Parkinson’s Disease model using Phosphoprotein isotope-coded solid-phase tags. Int J Neuroprotec Neuroregen 1(2): 98-106, 2005.